Custom Liquids High-Resolution NMR Probes
We have new model of our HR Liquids and our PFG probes that can extend sample temperatures up to +300oC. For recent experimental results: “Temperature Dependence of the 13C NMR of Nylon 6,6 — Liquids- Z Gradient Probe up to 300°C”
Large Samples, Inverse, Electrophoresis, PFG, MRI, Quad-Tuned and More
Many in the field of NMR immediately relate Doty Scientific with Solids NMR. We are proud of our contributions to NMR Solids, however, we would like people to know more about our contributions to liquids NMR as well.
Doty Scientific, an established leader in large-sample high-resolution (liquids) coil technology and solids NMR, is using the latest in laser cutting, compensated laminates, and thermal gradient minimization with alumina coilforms to bring its Super-B1 coils to high-resolution liquids NMR.
Following are examples of custom liquids high-resolution probes designed and built by Doty Scientific :
25 mm 1H/X liquids probe at 9.4 T
10 mm 1H/ 19F/X/lock, 400 MHz WB, Multi-X, Triple
10 mm 1H/X/Y/lock, 500 MHz NB, Multi-X, Multi-Y, Triple
10 mm 1H/X/lock, 300 MHz WB, Multi-X, -170°C to 500°C
5 mm 1H/X/lock, 600 MHz NB, Inverse, PFG, 220 G/cm continuous
5 mm 1H-19F/X/Y, 300 MHz NB, Inverse, Triple, PFG, -170°C to 300°C
15 mm 1H/X, 600 MHz NB, Multi-X, Microscopy, 25 G/cm continuous
15 mm 1H/19F/X, 600 MHz WB, Electrophoresis, PFG, 140 G/cm continuous
40 mm 1H/19F, 400 MHz WB, Microscopy Clear Bore, 14 G/cm continuous
18 mm 1H/X/lock, 600 MHz, NB, In-vivo
5 mm 1H/X/lock, 1067 MHz (1.07 GHz) NB Multi-X, PFG, 77 G/cm continuous
10 mm 1H/X/lock, 300 MHz High Temp PFG, 500°C
Recent results at the Advanced Imaging Research Center, Southwestern Medical Center at Dallas, Texas, USA, demonstrate the quality and versatility of Doty liquids probes.
![13C spectrum for a perfused heart in DOTY 25 mm 1H/X liquids probe at 9.4 T. The heart was perfused with hyperpolarized 2 mM [1-13C]pyruvate and natural abundance, unpolarized 2 mM octanoate. The metabolic products lactate and alanine are visible after a single 66 degree detection pulse. The octanoate effectively blocks production of the bicarbonate, which would normally be about the size of the lactate. The linewidths were ~12 Hz for 13C on the beating heart. Spectrum courtesy of: Dr. Matthew E. Merritt, Assistant Professor, Advanced Imaging Research Center, Southwestern Medical Center at Dallas](https://dotynmr.com/wp-content/uploads/2013/06/perfused_heart.jpg)
The heart was perfused with hyperpolarized 2 mM [1-13C]pyruvate and natural abundance, unpolarized 2 mM octanoate. The metabolic products lactate and alanine are visible after a single 66 degree detection pulse. The octanoate effectively blocks production of the bicarbonate, which would normally be about the size of the lactate. The linewidths were ~12 Hz for 13C on the beating heart. Spectrum courtesy of: Dr. Matthew E. Merritt, Assistant Professor, Advanced Imaging Research Center, Southwestern Medical Center at Dallas
Spectra Courtesy of Dr Warren Warren (Princeton) and NHMFL, Florida
1-cyclohexyl-2-pyrolidinone at 270°C.
Courtesy of Bruce Wade and A. S. Abhiraman, Georgia Institute of Technology
and by Stephen Wharry and Dirk Sutherlin, Phillips Petroleum.
Our discussion of liquids NMR, would not be complete without mention of our BMAX probes and the XC MAS probes. These versatile probes were designed specially to provide adequate resolution for the user to do HR MAS on solids, tissues, or liquids.
