The Resonator

Doty Scientific was awarded a Small Business Innovation Research (SBIR) research grant from the National Institutes of Health (NIH) for development of a 30 K MAS-DNP probe. The award started on September 30, 2013.

This SBIR project will enable 30 K MAS-DNP operation by developing: (A) the needed high-stability 30 K helium spinner technology, (B) the needed high- efficiency closed-loop cryogenic helium recycling system, and (C) the complete quad-resonance (¹H-¹³C-¹⁵N-electrons) DNP probe with auto sample exchange and extended variable temperature (XVT) operation for use initially in a 7 T magnet with the second design optimized at 11.7 T.

Signal acquisition with the proposed fully optimized MAS-DNP probe at 30 K could often improve sample throughput by one to two orders of magnitude compared to current state-of-the-art (100 K) MAS-DNP instrumentation, allowing the information needed for determining detailed molecular structures to be obtained on many complex biomolecules, catalysts, and other solids in an hour rather than days.

“… Strength of this application is ample experience of the investigators and their previous success in developing several NMR probes. The proposed spinner is very innovative …”