Ever Higher – 15.2 T MRI, 1H and 2H Imaging
Doty Scientific supplied a unique 15.2 T, 1H –19F/X MRI coil for mouse body (or rat brain). The coil was delivered to the Weizmann Institute just before the ENC in 2024. The high field strength, 15.2 T, and tight spacing (59 mm OD with two coils and a 36 mm ID) made this dual-frequency coil quite challenging. The dual-frequency coil has one coil for high frequency, H-F, where the coil is tunable from 1H to 19F. The multinuclear X channel was tuned to 2H for the study of pregnant mice, but can be tuned to many nuclei.
Below: Impressive MRI 1H and 2H results on a pregnant mouse (E16.5) were recorded in ~2 minute intervals following injection of saline D2O, providing water transport information across the placentas and into individual fetal organs at a level never before seen.
“The probe works very nicely – and it’s really a relief to be able to target the full pregnant animal on 1H and 2H without having to search positions fetus-by-fetus with a surface coil.” – Lucio
A Poster which was a collaboration between Doty Scientific and Weizmann Institute, was presented at the ENC in April 2025. “A Multi-nuclear Volume Coil for H/X Pre-clinical MR at Ultra High Magnetic Fields”
